Procedures, and for the management of benzodiazepine overdose. Where sedation has been produced with benzodiazepines for diagnostic and therapeutic General anesthesia has been induced and/or maintained with benzodiazepines, Partial reversal of the sedative effects of benzodiazepines in cases where Each mL contains 0.1 mg of flumazenil compounded with 1.8 mg of methylparaben, 0.2 mg of propylparaben, 0.9% sodium chloride, 0.01% edetate disodium, and 0.01% acetic acid the pH is adjusted to approximately 4 with hydrochloric acid and/or, if necessary, sodium hydroxide.įlumazenil injection is indicated for the complete or Flumazenil injection is available as a sterile parenteral dosage form for intravenous administration. It is insoluble in water but slightly soluble in acidic aqueous solutions. Flumazenil has an imidazobenzodiazepine structure, a calculated molecular weight of 303.3, and the following structural formula:įlumazenil is a white to off-white crystalline compound with an octanol: buffer partition coefficient of 14 to 1 at pH 7.4. Chemically, flumazenil is ethyl 8- fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo(1,4) benzodiazepine-3-carboxylate. DESCRIPTIONįlumazenil Injection, USP is a benzodiazepine receptor antagonist. You may report side effects to FDA at 1-80. For more information, ask your doctor or pharmacist.Ĭall your doctor for medical advice about side effects. These are not all the possible side effects of Romazicon. Tell the doctor if you have any side effect that bothers you or that does not go away.
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